La Salpingo-oforectomía o Salpingectomía como estrategia para prevenir el cáncer de ovario

Authors

  • Scarlet Hochstatter Irarrázabal Hospital Obrero No.2 -CNS
  • Erwin Hochstatter Arduz Hospital Obrero No.2 -CNS

DOI:

https://doi.org/10.58296/rm.v27i1.29

Keywords:

Salpingectomia, Ooforectomia, cáncer, mutaciones BRCA1, BRCA2

Abstract

Se dispone de abundante información relacionada con la carcinogénesis de los tumores epiteliales de ovario de alto grado, sabiéndose hoy que la mayoría de los carcinomas serosos de alto grado, endometriodes y de células claras del ovario derivan de la trompa de Falopio y no directamente del ovario. En esta revisión se pretende determinar si la extirpación de las trompas de Falopio sin ooforectomia puede permitir a las mujeres que tienen mutaciones BRCA1 o BRCA2 reducir su riesgo de cáncer de ovario y al mismo tiempo evitar la menopausia precoz y mantener su calidad de vida. Se ha desarrollado una teoría en relación con que la salpingectomía sola en mujeres que tienen mutaciones BRCA1 o BRCA2 y en aquellas que se desconozca si poseen esta mutación ofrecería una excelente alternativa para disminuir el riesgo de cáncer de ovario.

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Author Biographies

Scarlet Hochstatter Irarrázabal, Hospital Obrero No.2 -CNS

Ginecologa Obstetra

Erwin Hochstatter Arduz, Hospital Obrero No.2 -CNS

Ginecologo Obstetra – Hospital Obrero No.2 -CNS

References

Ferlay J, Shin B, Bray F, et al. Globocan 2008 v2.0, Cancer Incidence and Mortality Worldwide: IARC Cancer Base No. 10[internet]. Lyon, France. In: International Agency for Research on Cancer; 2010. [http://www.eurosafeimaging.org/wp/wpcontent/uploads/2015/05/Global-CancerStatistics.pdf]

Lowe K, Chia V, Taylor A, et al. An international assessment of ovarian cancer incidence and mortality. Gynecol Oncol 2013;130:107- 14. [https://pubmed.ncbi.nlm.nih.gov/23558050/] DOI: https://doi.org/10.1016/j.ygyno.2013.03.026

American Cancer Society,2007. Cancer Facts and Figures. [ www.cancer.org.Links ]

Ferlay J, Shin B, Bray F, et al. Globocan 2008 v 2.0, Cancer Incidence and Mortality Worldwide: IARC Cancer Base No. 10 [internet]. Lyon, France. In: International Agency for Research on Cancer; 2010 [ http://www.eurosafeimaging.org/wp/wp-content/uploads/2015/05/Global-Cancer-Statistics.pdf]

Vang R, Shih I, Kurman R. Ovarian lowgrade and high-grade serous carcinoma:Pathogenesis, clinic pathologic and molecular biologic features, and diagnostic problems. Adv Anat Pathol 2009,16:267-82. [ https://www.remedypublications.com/open-access/mucinous-differentiation-in-a-high-gradeserous-epithelial-ovarian-carcinoma-7871.pdf] DOI: https://doi.org/10.1097/PAP.0b013e3181b4fffa

Gómez-Pue D,1 Ibarrola-BuenAbad E,2 Lara-Núñez D,2 Vázquez-Alvarado AP,2 Pérez-Quintanilla M1. Salpingectomía como

opción de reducción del riesgo de cáncer de ovario. https://www.medigraphic.com/cgibin/new/resumen.cgi?IDARTICULO=73226

Foulkes WD. Preventing ovarian cancer by salpingectomy. Curr Oncol 2013;20(3):139-42. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3671016/ DOI: https://doi.org/10.3747/co.20.1613

JILL DELSIGNE-RUSSELL. La extirpación de las trompas de Falopio puede reducir el riesgo del cáncer de ovario [ https://www.mdanderson.org/es/publicaciones/oncolog/febrero-2017/laextirpacion-de-las-trompas-de-falopio-puedereducir-el-riesgo.html]

Fujiwara M, McGuire VA, Felberg A, Sieh W, Whittemore AS, Longacre TA (2012). Prediction of BRCA1 germline mutation status in

women with ovarian cancer using morphologybased criteria. Identification of a BRCA1 ovarian cancer phenotype. Am J Surg Pathol

:1170-1177. https://pubmed.ncbi.nlm.nih.gov/22790858/

Aziz S, Kuperstein G, Rosen B, Cole D, Nedelcu R, McLaughlin J, et al. A genetic epidemiological study of carcinoma of the

fallopian tube. Gynecol Oncol 2001;80(3):341–5. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3422129/ DOI: https://doi.org/10.1006/gyno.2000.6095

Parkin DM, Boyd L, Walker LC. 16. The fraction of cancer attributable to lifestyle and environmental factors in the UK in 2010. Br J

Cancer 2011;105(suppl 2):S77–81. [ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3252065/]

CRUK. Ovarian cancer risk factors. Available at: http://www.cancerresearchuk.org/healthprofessional/cancer-statistics/statistics-by-cancertype/ovarian-cancer#heading-Three. Retrieved July 23, 2017. [ https://www.cancerresearchuk.org/about-cancer/ovarian-cancer/risks-causes]

Havrilesky LJ, Moorman PG, Lowery WJ,Gierisch JM, Coeytaux RR, Urrutia RP, et al. Oral contraceptive pills asprimary prevention for

ovarian cancer: a systematic review and metaanalysis. Obstet Gynecol 2013; 122:139–47. [https://pubmed.ncbi.nlm.nih.gov/23743450/]

Iodice S, Barile M, Rotmensz N, Feroce I, Bonanni B, Radice P, et al. Oral contraceptive use and breast or ovarian cancer risk in BRCA1/2

carriers: a meta-analysis. Eur J Cancer 2010; 46:2275–84. [ https://www.ncbi.nlm.nih.gov/books/NBK78737/] DOI: https://doi.org/10.1016/j.ejca.2010.04.018

Collaborative Group on Epidemiological Studies of Ovarian Cancer, Beral V, Gaitskell K, Hermon C, Moser K, Reeves G, et al. Menopausal

hormone use and ovarian cancer risk: individual participant meta-analysis of 52 epidemiological

studies. Lancet 2015; 385:1835–42. https://www.nature.com/articles/bjc201735 DOI: https://doi.org/10.1016/S0140-6736(14)61687-1

Manual SEOM de prevención y diagnóstico precoz del cáncer. https://seom.org/manualprevencion/211/#zoom=z

Sung HK, Ma SH, Choi JY, Hwang Y, Ahn C, Kim BG, et al. The effect of breastfeeding duration and parity on the risk of epithelial ovarian cancer: a systematic review and meta-analysis. J Prev Med Public Health 2016; 49:349–66. [ https://pubmed.ncbi.nlm.nih.gov/27951628/] DOI: https://doi.org/10.3961/jpmph.16.066

Madsen C, Baandrup L, Dehlendorff C, Kjaer SK. Tubal ligation and salpingectomy and the risk of epithelial ovarian cancer and

borderline ovarian tumors: a nationwide casecontrol study. Acta Obstet Gynecol Scand 2015; 94:86–94. [ https://pubmed.ncbi.nlm. DOI: https://doi.org/10.1111/aogs.12516

nih.gov/25256594/]

Haruta S, Furukawa N, Yoshizawa Y, et al. Molecular genetics and epidemiology of epithelial ovarian cancer (Review). Oncol

Reports 2011; 26:1347-56. [ https://pubmed.ncbi.nlm.nih.gov/21922146/]

Brewer M, Johnson K, Follen M, et al.Prevention of ovarian cancer: intraepithelial neoplasia. Clin Cancer Res 2003; 9:20-30. [ http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-75262015000500011]

Yoon SH, Kim SN, Shim SH, Kang SB, Lee SJ. Bilateral salpingectomy can reduce the risk of ovarian cancer in the general population: A

metaanalysis. Eur J Cancer. 2016 Mar; 55:38-46. https://www.acog.org/clinical/clinicalguidance/committee-opinion/articles/2019/04/

opportunistic-salpingectomy-as-a-strategy-forepithelial-ovarian-cancer-prevention

Kho RM, Wechter ME. Operative Outcomes of Opportunistic Bilateral Salpingectomy at the Time of Benign Hysterectomy in LowRisk Premenopausal Women: A Systematic Review. J Minim Invasive Gynecol. 2017 Feb;24(2):218-229. [https://pubmed.ncbi.nlm. DOI: https://doi.org/10.1016/j.jmig.2016.12.004

nih.gov/27988392/]

Kurman RJ, Shih I. The dualistic model of ovarian carcinogenesis: revisited, revised, and

expanded. Am J Pathol 2016; 186:733–47. [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5808151/]

Kuhn E, Kurman RJ, Vang R, Sehdev AS, Han G, Soslow R, et al. TP53 mutations in serous tubal intraepithelial carcinoma and

concurrent pelvic high-grade serous [ https://pubmed.ncbi.nlm.nih.gov/21990067/]

Eva Ruvalcaba-Limón, Araceli SilvaGarcía, Carlos Eduardo Aranda-Flores, Félix Quijano-Castro, Joel BañuelosFlores, Gonzalo Montalvo-Esquivel y Milagros Clementina Pérez-Quintanilla.Factores de riesgo, factores protectores y etapificación [ https://biblat.unam.mx/hevila/

Gacetamexicanadeoncologia/2018/vol17/supl2/1.pdf]

Factores de Riesgo del Cáncer de Ovario.

https://www.elsevier.es/es-revista-progresosobstetricia-ginecologia-151-articulo-factoresriesgo-pronostico-screening-el-10017243

Gustavo Romero Gutiérrez, Jaime Naves

Sánchez, Alejandra Horna López, Carlos Julio

Aspe Lucero, Roberto Molina Rodríguez,

Ana Lilia Ponce Ponce de León. Factores de

riesgo asociados con cáncer de ovario. https://

www.medigraphic.com/cgi-bin/new/resumen.

cgi?IDARTICULO=6472

Laura Yuriko González-Teshima; Fabio

Samir Vargas-Cely; Juan Sebastián MuñozSandoval, MD; Julián Ramírez-Cheyne, MD ;

Wilmar Saldarriaga-Gil, MD, MSc. Síndrome

de cáncer hereditario de mama y ovario:

aplicación clínica [ http://www.scielo.org.co/

scielo.php?script=sci_arttext&pid=S0034-

#:~:text=El%20

s%C3%ADndrome%20de%20

c%C3%A1ncer%20hereditario%20

de%20mama%20y%20ovario%20

(SCHMO,BRCA2%20localizados%20en%20

el%20cromosoma]

Cristina Isabel Martínez1, Luis Francisco

Pérez1, David Baquero2, Andrés Barco2.

Cáncer colorrectal hereditario no asociado a

poliposis o síndrome de Lynch. Rev Colomb

Cir. 2017; 32:297-303 [ http://www.scielo.org. DOI: https://doi.org/10.30944/20117582.38

co/pdf/rcci/v32n4/v32n4a9.pdfLinks ]

Sindrome de Peutz y Jeghers [ https://

www.cancer.net/cancer-types/peutz-jegherssyndrome#:~:text=PJS%20is%20a%20

genetic%20condition,known%20as%20the%20

LKB1%20gene. ]

Sampson JR, Dolwani S, Jones S, Eccles D,

Ellis A, Evans DG, et al. Autosomal recessive

colorectal adenomatous polyposis due to

inherited mutations of MYH. Lancet. 2003;

:39-41. [ https://pubmed.ncbi.nlm.nih.

gov/12853198/]

https://www.elsevier.es/es-revistaprogresos-obstetricia-ginecologia-151-

articulo-estimulacion-folicular-ovarica-riesgocancer-13009680

https://www.cdc.gov/spanish/especialescdc/

cancereshereditarios/index.html Cáncer de

mama y de ovario hereditarios

Nicolás Padilla-Raygoza, Rebeca MonroyTorres, Cuauhtémoc SandovalSalazar, Luz

Elvia Vera-Becerra, María Esther Patiño-López,

María de Lourdes García-Campos y otros.

Programas de prevención de cáncer en México:

¿estamos haciendo lo suficiente? [ https://

ecancer.org/es/journal/article/997-cancerprevention-programmes-in-mexico-are-wedoing-enough/pdf/es]

Hartmann LC, Lindor NM. The role of

risk-reducing surgery in hereditary breast and

ovarian cancer. N Engl J Med 2016374:454–68. [

https://pubmed.ncbi.nlm.nih.gov/27305204/]

Marchetti C, De Felice F, Palaia I, Perniola G,

Musella A, Musio D, et al. Risk-reducing salpingooophorectomy: a meta-analysis on impact on

ovarian cancer risk and all-cause mortality in

BRCA 1 and BRCA 2 mutation carriers. BMC

Womens Health 2014; 14:150. https://www.ncbi.

nlm.nih.gov/pmc/articles/PMC4271468/

Leblanc E, Narducci F, Farre I, Peyrat JP,

Taieb S, Adenis C, et al. Radical fimbriectomy:

a reasonable temporary riskreducing surgery for

selected women with a germ line mutation of

BRCA 1 or 2 genes? Rationale and preliminary

development. Gynecol Oncol 2011; 121:472–6. [

https://pubmed.ncbi.nlm.nih.gov/21411127/]

Finch A, Beiner M, Lubinski J, Lynch HT,

Moller P, Rosen B, et al. Salpingo-oophorectomy

and the risk of ovarian, fallopian tube, and

peritoneal cancers in women with a BRCA1 or

BRCA2 mutation. JAMA 2006; 296:185–92. [ DOI: https://doi.org/10.1001/jama.296.2.185

https://pubmed.ncbi.nlm.nih.gov/16835424/]

Falconer H, Yin L, Gronberg H, Altman

D. Ovarian cancer risk after salpingectomy: a

nationwide population-based study. J Natl Cancer

Inst 2015 Jan 27. [https://europepmc.org/article/

med/25628372].

Darelius A, Lycke M, Kindblom JM,

Kristjansdottir B, Sundfeldt K, Strandell A.

Efficacy of salpingectomy at hysterectomy to

reduce the risk of epithelial ovarian cancer: a

systematic review. BJOG 2017;124:880–9. [ DOI: https://doi.org/10.1111/1471-0528.14601

https://obgyn.onlinelibrary.wiley.com/doi/

abs/10.1111/1471-0528.14601]

Manchanda R. Opportunistic salpingectomy

for prevention of ovarian cancer. BJOG 2017;

:890. [ Links ]

Ying Chen , Hui Du , Lewen Bao y Wenxin

Liu. Salpingectomía oportunista en cirugía

ginecológica benigna para reducir el riesgo de

cáncer de ovario: una experiencia de 10 años

en un solo centro de China y una revisión de la

literatura

Vang R, Shih I, Kurman R. Ovarian low-grade

and high-grade serous carcinoma: Pathogenesis,

clinic pathologic and molecular biologic features,

and diagnostic problems. Adv Anat Pathol

,16:267-82. [ https://pubmed.ncbi.nlm.

nih.gov/19700937/]

Guía de práctica clínica en cáncer hereditario

de la Comunitat Valenciana. Tercera edición. 2017.

Conselleria de Sanitat Universal I Salut Pública

Generalitat. [https://portal.guiasalud.es/gpc/

cancer-hereditario/] [Consulta: 03/05/2021]

Jacobson M, Coakley N, Bernardini M,

Elit L, Ferguson SE, Kim R. Risk Reduction

Strategies for BRCA1/2 Hereditary Ovarian

Cancer Syndromes Toronto (ON): Ontario

Health (Cancer Care Ontario); 2020 September

Program in Evidence-Based Care Guideline

No.: 4-4. https://www.ncbi.nlm.nih.gov/

pmc/articles/PMC8474940/Version [https://

www.cancercareontario.ca/en/file/56691/

download?token=nZtHkYf7] [Consulta:

/05/2021]

Kwon JS, Tinker A, Pansegrau G, McAlpine

J, Housty M, McCullum M, et al. Prophylactic

salpingectomy and delayed oophorectomy as an

alternative for BRCA mutation carriers. Obstet

Gynecol 2013; 121:14–24. [ https://europepmc. DOI: https://doi.org/10.1016/j.neucom.2013.01.030

org/article/med/23232752]

Anderson M. Prophylactic salpingectomy with

delayed oophorectomy, risk-reducing salpingooophorectomy, and ovarian cancer screening

among BRCA mutation carriers: a proof-ofconcept study (study #2013-0340). Available at:

https://www.mdanderson.org/patients-family/

diagnosis-treatment/clinical-trials/clinical-trialsindex/clinical-trials-detail. ID2013-0340.html.

Retrieved July 23, 2017.

Veiga-Fernández, Amanda, Luque-Molina,

María del Sol,, Ferreres-García, Karla1

Mendizábal-Vicente, Elsa María Rincón-Olbes,

Patricia

Lizárraga-Bonelli, Santiago [ https://www.

scielo.org.mx/scielo.php?pid=S0300-

&script=sci_arttext_

plus&tlng=es Links ]

McAlpine J, Hanley G, Woo M, et al. Ovarian

cancer research program of British Columbia.

Opportunistic salpingectomy: uptake, risks, and

complications of a regional initiative for ovarian

cancer prevention. Am J Obstet Gynecol 2014;

:471. e1-e11. [ https://www.ajog.org/article/

S0002-9378%2814%2900014-3/abstract ]

Mohamed AA, Yosef AH, James C, AlHussaini TK, Bedaiwy MA, Amer SAKS. Ovarian

reserve after salpingectomy: a systematic review

and meta-analysis. Acta Obstet Gynecol Scand

; 96:795–803. [https://obgyn.onlinelibrary.

wiley.com/doi/pdf/10.1111/aogs.13133 ]

Gan C, Chenoy R, Chandrasekaran D,

Brockbank E, Hollingworth A, Vimplis S, et

al. Persistence of fimbrial tissue on the ovarian

surface after salpingectomy. Am J Obstet Gynecol

; 217:425. e1–16. [ https://www.wjgnet.

com/2218-4333/CitedArticlesInF6?id=10.1111%

Fhis.12419]

Nowak M, Janas Ł, Stachowiak G, Stetkiewicz

T, Wilczyński JR. Current clinical application

of serum biomarkers to detect ovarian cancer.

Prz Menopauzalny. 2015;14(4):254-9. [Current DOI: https://doi.org/10.9785/gesr-2015-0410

clinical application of serum biomarkers to detect

ovarian cancer. - Abstract - Europe PMC ]

https://www.aarp.org/espanol/salud/expertos/

elmer-huerta/info-2016/talco-y-minerales-quecausan-cancer.html

Published

2023-03-12

How to Cite

1.
Hochstatter Irarrázabal S, Hochstatter Arduz E. La Salpingo-oforectomía o Salpingectomía como estrategia para prevenir el cáncer de ovario. RM [Internet]. 2023 Mar. 12 [cited 2024 Dec. 23];27(1):26-34. Available from: https://revista-medica-cbba.com/index.php/rm/article/view/29